Antiviral drug discovery and development : Article : Nature Reviews Drug Discovery

Nature Reviews Drug Discovery: "In the mid-1990s, a new class of antiviral drugs known as HIV protease inhibitors revolutionized the treatment of HIV infection. Being involved in this transformation has been the best career experience for Joseph Vacca, Executive Director of the Department of Medicinal Chemistry at Merck, who was the project leader and one of the co-inventors of the first-generation HIV protease inhibitor indinavir. "